In the laboratory of the largest Institute of Physical and Chemical Research (RIKEN), Japanese specialists managed to grow artificial skin in a Petri dish, which was then implanted by rodents. According to scientists, the newly created tissue not only successfully took root, forming compounds with the nervous and muscle tissues, but also included hair follicles and sweat glands.
RIKEN employees under the leadership of Takashi Tsuji previously conducted similar studies in this direction, however, the grown tissues could not normally provide such functions as, for example, sweating, due to the lack of sweat and sebaceous glands.
The new artificial skin, in addition to performing all its basic functions, also has a normal structure: 3 layers (epidermis, dermis and subcutaneous fat).
To create a new tissue, scientists used pluripotent stem cells obtained by epigenetic reprogramming from the epithelium of rodent gums. Specialists grew artificial skin fragments in Petri dishes, and subsequently implanted them into laboratory animals. According to the results of observations, hair follicles, sweat and sebaceous glands formed in the transplanted tissue. Two weeks later, hair growth began.
The researchers found that the implanted tissues have a normal three-layer structure, their functioning is not disturbed, the rodent immune system did not cause rejection of the transplanted skin.
“Our results are evidence of the existence of a new successful method of regenerative medicine, which in the future will find wide application in clinical practice,” - Takashi Tsuji.
Japanese experts hope that the technology they developed to recreate the outer skin of the body will help not only patients who have severe burns or suffer from chronic skin diseases, but also pharmacologists, as an alternative way to study the effect of the drug or cosmetics.
Currently, researchers are conducting experiments to create teeth and salivary glands from pluripotent cells. The scientific work of RIKEN employees was published in the journal Science Advances.
The article is based on materials .
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